Most Accessed Articles: Hereditary Cancer in Clinical Practicehttps://hccpjournal.biomedcentral.comMost Accessed Articles: Hereditary Cancer in Clinical PracticeCancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical managementhttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-7-17Lynch syndrome (LS) is associated with a high risk for colorectal cancer (CRC) and extracolonic malignancies, such as endometrial carcinoma (EC). The risk is dependent of the affected mismatch repair gene. The...ResearchWed, 23 Dec 2009 00:00:00 GMThttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-7-17Dewkoemar Ramsoekh, Anja Wagner, Monique E van Leerdam, Dennis Dooijes, Carli MJ Tops, Ewout W Steyerberg and Ernst J Kuipers2009-12-23T00:00:00ZThe role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancershttps://hccpjournal.biomedcentral.com/articles/10.1186/s13053-015-0038-xThe association of germline mutations in the breast cancer susceptibility gene 1 (BRCA1) and the breast cancer susceptibility gene 2 (BRCA2) with the development of breast and ovarian cancers have been widely res...ReviewSat, 01 Aug 2015 00:00:00 GMThttps://hccpjournal.biomedcentral.com/articles/10.1186/s13053-015-0038-xHelen Cavanagh and Katherine M.A. Rogers2015-08-01T00:00:00ZGermline deletions in the EPCAM gene as a cause of Lynch syndrome – literature reviewhttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-11-9Lynch syndrome (clinically referred to as HNPCC – Hereditary Non-Polyposis Colorectal Cancer) is a frequent, autosomal, dominantly-inherited cancer predisposition syndrome caused by various germline alteration...ReviewMon, 12 Aug 2013 00:00:00 GMThttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-11-9Katarzyna Tutlewska, Jan Lubinski and Grzegorz Kurzawski2013-08-12T00:00:00ZMSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancerhttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-8-5Approximately 10% of Lynch syndrome families have a mutation in MSH6 and fewer families have a mutation in PMS2. It is assumed that the cancer incidence is the same in families with mutations in MSH6 as in famili...ResearchFri, 21 May 2010 00:00:00 GMThttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-8-5Bente A Talseth-Palmer, Mary McPhillips, Claire Groombridge, Allan Spigelman and Rodney J Scott2010-05-21T00:00:00ZUnusual presentation of Lynch Syndromehttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-7-12Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR). The spectrum of cancer associated with Lynch Synd...Case reportWed, 03 Jun 2009 00:00:00 GMThttps://hccpjournal.biomedcentral.com/articles/10.1186/1897-4287-7-12Veronica PCC Yu, Marco Novelli, Stewart J Payne, Sam Fisher, Rebecca A Barnetson, Ian M Frayling, Ann Barrett, David Goudie, Audrey Ardern-Jones, Ros Eeles and Susan Shanley2009-06-03T00:00:00Z