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This article is part of the supplement: Proceedings of the 14th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer

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Risks of cancers for carriers of monoallelic MUTYH mutation with a family history of colorectal cancer

Aung K Win1, Sean P Cleary23, James G Dowty1, Noralane M Lindor4, Polly A Newcomb5, Robert W Haile6, Joanne P Young7, Daniel D Buchanan7, Loïc Le Marchand8, Roger Green9, John L Hopper1, Steven Gallinger23 and Mark A Jenkins1*

Author Affiliations

1 Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria 3010 Australia

2 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

3 Cancer Care Ontario, Toronto, Ontario, Canada

4 Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota, USA

5 Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

6 Familial Cancer Laboratory, Queensland Institute of Medical Research, Herston, Brisbane Q4006 Australia

7 Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA

8 Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813 USA

9 Memorial University of Newfoundland, St. John's, Newfoundland, Canada

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Hereditary Cancer in Clinical Practice 2011, 9(Suppl 1):P40  doi:10.1186/1897-4287-9-S1-P40

The electronic version of this article is the complete one and can be found online at: http://www.hccpjournal.com/content/9/S1/P40


Published:10 March 2011

© 2011 Win et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Several studies have shown an increased risk of colorectal and extracolonic cancers for carriers of germline MUTYH mutations inherited from both parents (biallelic mutations). Extracolonic cancer risks for carriers of a MUTYH mutation inherited from only one parent (monoallelic mutation) have not previously been estimated.

Materials and methods

We identified 144 families of MUTYH mutation carriers from three countries that we ascertained through population-based sources of the multi-site, international Colon Cancer Family Registry. Mutation status, sex, age, and histories of cancer, polypectomy, and hysterectomy were sought from 2,179 of their relatives. Using Cox regression weighted to adjust for the method of ascertainment, we estimated the country-, age- and sex-specific standardized incidence ratios (SIRs) of colorectal and extracolonic cancers for monoallelic mutation carriers, compared with the general population, and corresponding age-specific cumulative risks.

Results

Monoallelic mutation carriers with a family history of CRC had a significantly increased incidence of CRC (SIR = 2.04; 95% confidence interval, CI = 1.56 – 2.70; P <0.001), gastric cancer (SIR = 3.24; 95% CI = 2.18 – 4.98; P <0.001), and endometrial cancer (SIR = 2.23; 95% CI = 1.13 – 4.86; P = 0.03) and a marginal increased incidence of liver cancer (SIR = 3.09; 95% CI = 1.07 – 12.25; P = 0.07) compared to the general population. The estimated cumulative risks to age 70 years based on the population cancer incidence of the United States were as follows: for CRC, 6% (95% CI = 5 – %) for men and 4% (95% CI = 3 – 6%) for women; for gastric cancer, 2% (95% CI = 1 – 3%) for men and 0.7% (95% CI = 0.5 – 1%) for women; for liver cancer, 1% (95% CI = 0.3 – 3%) for men and 0.3% (95% CI = 0.1 – 1%) for women; and for endometrial cancer, 4% (95% CI = 2 – 8%). There was no evidence of increased risks for cancer of the brain, pancreas, kidney, lung, breast or prostate.

Conclusion

Monoallelic MUTYH mutation carriers with a family history of CRC are at increased risk of colorectal, gastric, liver and endometrial cancers.

Acknowledgements

This abstract is presented for the Colon Cancer Family Registry and supported by the National Cancer Institute, National Institutes of Health under Request for Application #CA-95-011.