Research
Penetrance of HNPCC-related cancers in a retrolective cohort of 12 large Newfoundland families carrying a MSH2 founder mutation: an evaluation using modified segregation models
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* Corresponding author: Karen A Kopciuk kakopciu@ucalgary.ca
1 Division of Population Health Research, Alberta Health Services Board, Calgary, Alberta, Canada
2 Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, Canada
3 Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
4 Clinical Epidemiology Unit, Memorial University, St John's, Newfoundland, Canada
5 Population Studies and Surveillance, Cancer Care Ontario, Toronto, Ontario, Canada
6 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
7 Discipline of Genetics, Memorial University, St John's, Newfoundland, Canada
Hereditary Cancer in Clinical Practice 2009, 7:16 doi:10.1186/1897-4287-7-16
Published: 28 October 2009Additional files
Additional file 1:
General hazard specification for parametric regression model. The formulation of the hazard function based on a generalized log-Burr specification of the survival function.
Format: TEX Size: 7KB Download file
Additional file 2:
Retrospective Ascertainment-Corrected Likelihood. Details on the derivation of the correction for ascertainment of high risk families.
Format: TEX Size: 8KB Download file