Base excision repair and the role of MUTYH
1 Discipline of Medical Genetics, School of Biomedical Science, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute, Newcastle NSW, Australia
2 Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Newcastle NSW, Australia
Hereditary Cancer in Clinical Practice 2007, 5:199-209 doi:10.1186/1897-4287-5-4-199Published: 15 December 2007
The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development. The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how deterioration of this process is associated with an increased risk of malignancy.