Table 1 |
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|
Estimated cumulative risk of breast, ovarian and other cancer in first-degree relatives of BRCA1 founder mutation carriers |
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|
Parameters |
Cancer site in relative |
BRCA1 mutation type |
First-degree relatives with cancer/total |
Cancer risk to age of 50 |
Cancer risk to age of 75 |
|
|
|||||
|
Females |
breast |
5382insC |
60/557 |
0.15 |
0.29 |
|
|
|||||
|
C61G |
32/226 |
0.23 |
0.46 |
||
|
|
|||||
|
4153delA |
8/68 |
0.25 |
0.25 |
||
|
|
|||||
|
total |
100/851 |
0.18 |
0.33 |
||
|
|
|||||
|
ovary |
5382insC |
29/557 |
0.04 |
0.17 |
|
|
|
|||||
|
C61G |
3/226 |
0.01 |
0.05 |
||
|
|
|||||
|
4153delA |
6/68 |
0.08 |
0.38 |
||
|
|
|||||
|
total |
38/851 |
0.03 |
0.15 |
||
|
|
|||||
|
other |
5382insC |
22/557 |
0.03 |
0.15 |
|
|
|
|||||
|
C61G |
17/226 |
0.05 |
0.36 |
||
|
|
|||||
|
4153delA |
1/68 |
0.02 |
0.02 |
||
|
|
|||||
|
total |
40/851 |
0.04 |
0.19 |
||
|
|
|||||
|
any |
5382insC |
111/557 |
0.22 |
0.61 |
|
|
|
|||||
|
C61G |
52/226 |
0.29 |
0.87 |
||
|
|
|||||
|
4153delA |
15/68 |
0.36 |
0.66 |
||
|
|
|||||
|
total |
178/851 |
0.25 |
0.67 |
||
|
|
|||||
|
Males |
any |
5382insC |
47/553 |
0.03 |
0.36 |
|
|
|||||
|
C61G |
16/193 |
0.05 |
0.33 |
||
|
|
|||||
|
4153delA |
7/70 |
0.00 |
0.39 |
||
|
|
|||||
|
total |
70/816 |
0.03 |
0.35 |
||
|
|
|||||
|
Gronwald Hereditary Cancer in Clinical Practice 2007 5:3 doi:10.1186/1897-4287-5-1-3 |
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