This article is part of the supplement: Annual Conference on Hereditary Cancers 2011
Meeting abstract
Selenium and the risk of cancer of the lung and larynx. A case-control study from a region with low selenium
1 International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
2 Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland
3 Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland
4 Department of General Thoracic Surgery, Pomeranian Medical University, Szczecin, Poland
5 Maxillofacial Surgery, Pomeranian Medical University, Szczecin, Poland
6 Department of Toxicology and Molecular Pathobiochemistry, Pomeranian Medical University, Szczecin, Poland
7 Women’s College Research Institute, Toronto, ON, Canada
Hereditary Cancer in Clinical Practice 2012, 10(Suppl 3):A7 doi:10.1186/1897-4287-10-S3-A7
Published: 20 April 2012First paragraph (this article has no abstract)
Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer.
