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This article is part of the supplement: Annual Conference on Hereditary Cancers 2011

Open Access Meeting abstract

Selenium and the risk of cancer of the lung and larynx. A case-control study from a region with low selenium

Katrzyna Jaworska12*, Satish Gupta12, Katarzyna Durda1, Magdalena Muszynska1, Grzegorz Sukiennicki1, Elżbieta Jaworowska3, Tomasz Grodzki4, Mieczysław Sulikowski5, Piotr Woloszczyk6, Janusz Wójcik4, Jakub Lubiński3, Cezary Cybulski1, Tadeusz Dębniak1, Marcin Lener1, Steven A Narod7, Ping Sun7, Jan Lubiński1 and Anna Jakubowska1

Author Affiliations

1 International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

2 Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland

3 Department of Otolaryngology and Laryngological Oncology, Pomeranian Medical University, Szczecin, Poland

4 Department of General Thoracic Surgery, Pomeranian Medical University, Szczecin, Poland

5 Maxillofacial Surgery, Pomeranian Medical University, Szczecin, Poland

6 Department of Toxicology and Molecular Pathobiochemistry, Pomeranian Medical University, Szczecin, Poland

7 Women’s College Research Institute, Toronto, ON, Canada

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Hereditary Cancer in Clinical Practice 2012, 10(Suppl 3):A7  doi:10.1186/1897-4287-10-S3-A7

Published: 20 April 2012

First paragraph (this article has no abstract)

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer.