New and sporadic BRAF mutations in thyroid neoplasms. A, a new 3-base-pair deletion at codon 599 identified in a FA resulting in deletion of threonine 599 (p.T599del). B, a rare 3-base pair insertion at codon 599 found in an aggressive PTC resulting in duplication of threonine 599 (p.T599dup). Deleted and inserted nucleotides and codons are underlined.
Schulten et al. Hereditary Cancer in Clinical Practice 2012 10:10 doi:10.1186/1897-4287-10-10